Avison, Matthew B

Douglas, Edward J. A.

Dulyayangkul, Punyawee

Lsstovka, Filip

English

Serine β-lactamases are dominant causes of β-lactam resistance in Klebsiella pneumoniae. Recently, this has driven clinical deployment of the β-lactam/β-lactamase inhibitor pairs ceftazidime/avibactam and meropenem/vaborbactam. We show that four steps: ompK36 and ramR mutation plus carriage of OXA-232 and KPC-3-D178Y variant β-lactamases confer ceftazidime/avibactam and meropenem/vaborbactam resistance when both pairs are used together. These findings have implications for decision making about sequential and combinatorial use of these β-lactam/β-lactamase inhibitor pairs to treat K. pneumoniae infections

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Resistance to Ceftazidime/Avibactam Plus Meropenem/Vaborbactam When Both are Used Together Achieved in Four Steps from Metallo-β-Lactamase Negative &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt;.

https://research-information.bris.ac.uk/files/245955534/Dulyayangkul_et_al_2020a_AAC_Submitted_V3_1_.pdf

Resistance to Ceftazidime/Avibactam Plus Meropenem/Vaborbactam When Both are Used Together Achieved in Four Steps from Metallo-β-Lactamase Negative <i>Klebsiella pneumoniae</i>.

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Explore Bristol Research

Resistance to Ceftazidime/Avibactam Plus Meropenem/Vaborbactam When Both are Used Together Achieved in Four Steps from Metallo-β-Lactamase Negative &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt;.

Abstract

Similar works

Full text

Available Versions

Explore Bristol Research

Resistance to Ceftazidime/Avibactam Plus Meropenem/Vaborbactam When Both are Used Together Achieved in Four Steps from Metallo-β-Lactamase Negative <i>Klebsiella pneumoniae</i>.