The GenOSept project was supported by the European Critical Care Research network and the European Society of Intensive Care Medicin

Chiche, J-D

Clarke, GM

Garrard, CS

Gordon, AC

Hinds, CJ

Hutton, P

Investigators, ESICMECCRNG

McKechnie, S

Rello, J

Stueber, F

Walden, AP

PubMed

Andrew P Walden

Geraldine M Clarke

Stuart McKechnie

Paula Hutton

Anthony C Gordon

Jordi Rello

Jean-Daniel Chiche

Frank Stueber

Christopher S Garrard

Charles J Hinds

null null

Springer - Publisher Connector

Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort

INTRODUCTION



Community acquired pneumonia (CAP) is the most common infectious reason for admission to the Intensive Care Unit (ICU). The GenOSept study was designed to determine genetic influences on sepsis outcome. Phenotypic data was recorded using a robust clinical database allowing a contemporary analysis of the clinical characteristics, microbiology, outcomes and independent risk factors in patients with severe CAP admitted to ICUs across Europe.



METHODS



Kaplan-Meier analysis was used to determine mortality rates. A Cox Proportional Hazards (PH) model was used to identify variables independently associated with 28-day and six-month mortality.



RESULTS



Data from 1166 patients admitted to 102 centres across 17 countries was extracted. Median age was 64 years, 62% were male. Mortality rate at 28 days was 17%, rising to 27% at six months. Streptococcus pneumoniae was the commonest organism isolated (28% of cases) with no organism identified in 36%. Independent risk factors associated with an increased risk of death at six months included APACHE II score (hazard ratio, HR, 1.03; confidence interval, CI, 1.01-1.05), bilateral pulmonary infiltrates (HR1.44; CI 1.11-1.87) and ventilator support (HR 3.04; CI 1.64-5.62). Haematocrit, pH and urine volume on day one were all associated with a worse outcome.



CONCLUSIONS



The mortality rate in patients with severe CAP admitted to European ICUs was 27% at six months. Streptococcus pneumoniae was the commonest organism isolated. In many cases the infecting organism was not identified. Ventilator support, the presence of diffuse pulmonary infiltrates, lower haematocrit, urine volume and pH on admission were independent predictors of a worse outcome

Walden, Andrew P

Clarke, Geraldine M

McKechnie, Stuart

Hutton, Paula

Gordon, Anthony C

Rello, Jordi

Chiche, Jean-Daniel

Stueber, Frank

Garrard, Christopher S

Hinds, Charles J

Bern Open Repository and Information System (BORIS)

Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort.

INTRODUCTION: Community acquired pneumonia (CAP) is the most common infectious reason for admission to the Intensive Care Unit (ICU). The GenOSept study was designed to determine genetic influences on sepsis outcome. Phenotypic data was recorded using a robust clinical database allowing a contemporary analysis of the clinical characteristics, microbiology, outcomes and independent risk factors in patients with severe CAP admitted to ICUs across Europe. METHODS: Kaplan-Meier analysis was used to determine mortality rates. A Cox Proportional Hazards (PH) model was used to identify variables independently associated with 28-day and six-month mortality. RESULTS: Data from 1166 patients admitted to 102 centres across 17 countries was extracted. Median age was 64 years, 62% were male. Mortality rate at 28 days was 17%, rising to 27% at six months. Streptococcus pneumoniae was the commonest organism isolated (28% of cases) with no organism identified in 36%. Independent risk factors associated with an increased risk of death at six months included APACHE II score (hazard ratio, HR, 1.03; confidence interval, CI, 1.01-1.05), bilateral pulmonary infiltrates (HR1.44; CI 1.11-1.87) and ventilator support (HR 3.04; CI 1.64-5.62). Haematocrit, pH and urine volume on day one were all associated with a worse outcome. CONCLUSIONS: The mortality rate in patients with severe CAP admitted to European ICUs was 27% at six months. Streptococcus pneumoniae was the commonest organism isolated. In many cases the infecting organism was not identified. Ventilator support, the presence of diffuse pulmonary infiltrates, lower haematocrit, urine volume and pH on admission were independent predictors of a worse outcome

Chiche, JD

Oxford University Research Archive (ORA)

Critical Care

Crossref

Oxford University Research Archive

Spiral - Imperial College Digital Repository

English

Patients with community acquired pneumonia admitted to European Intensive Care Units: an epidemiological survey of the GenOSept cohort

Queen Mary Research Online

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Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort

Abstract

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Springer - Publisher Connector

Springer - Publisher Connector

Bern Open Repository and Information System (BORIS)

Oxford University Research Archive (ORA)

Crossref

Oxford University Research Archive

Spiral - Imperial College Digital Repository

Queen Mary Research Online