Hawking, MKD

Horne, R

Robson, JP

Taylor, SJC

International Journal of Behavioral Medicine

Queen Mary Research Online

Individual Oral/Poster Abstract Example/Template: Investigating patients’ perspectives towards and adherence to Non Vitamin K Antagonist Oral Anticoagulants (NOACs) for atrial fibrillation: a UK Based prospective mixed methods study. M.K.D. Hawking1, J.P. Robson1, S.J.C. Taylor1 & R. Horne21Centre for Primary Care and Public Health, Bart’s and the London Medical School, Queen Mary University of London, LONDON, UK2Centre for Behavioural Medicine, School of Pharmacy, University College London, LONDON, UKIntroduction: Non-Vitamin K antagonist oral anticoagulants (NOACs) have been approved for use in the UK for the prevention of strokes amongst patients with non-valvular atrial fibrillation (AF). Long term anticoagulant therapy reduces stroke risk by 64%, however adherence to the dosage regime is critical, as the effect of a NOAC diminishes rapidly 12-24 hours after ingestion. In contrast to warfarin, monitoring to assess coagulation levels is not required for NOACs, but the effect this may have on patient adherence has yet to be investigated. This study aims to investigate levels of adherence amongst patients who begin taking NOACs and to explore the determinants of non-adherence in this context.Methods: NOAC-naïve patients with AF were recruited from anticoagulant clinics in five boroughs across London and the South West of England, and followed up prospectively for six months after initiation. Four telephone surveys using validated survey instruments (MARs, B-IPQ, modified-BMQ) were undertaken, at baseline, one, three and six month time points. A subset of patients were purposively sampled from the cohort and undertook semi-structured qualitative interviews.Results: Kaplan-Meier survival curves will be calculated to analyse NOAC persistence over the follow up period. Regression will be used to identify any variables associated with self-reported non-adherence at each of the time points. The qualitative findings will be thematically analysed.Conclusions: The findings from the study will be used to inform the development of an intervention to improve patients’ experience of NOAC therapy and support adherence.CORRESPONDING AUTHOR: M.K.D. Hawking, Centre for Primary Care and Public Health, Bart’s and the London Medical School, Queen Mary University of London, LONDON, UKWord count: 241 

INVESTIGATING PATIENTS' PERSPECTIVES TOWARDS AND ADHERENCE TO NON VITAMIN K ANTAGONIST ORAL ANTICOAGULANTS (NOACS) FOR ATRIAL FIBRILLATION: A UK BASED PROSPECTIVE MIXED METHODS STUDY.

https://qmro.qmul.ac.uk/xmlui/bitstream/123456789/24523/1/Hawking%20ICBM%20NOAC%20Abstract%202016.doc

INVESTIGATING PATIENTS' PERSPECTIVES TOWARDS AND ADHERENCE TO NON VITAMIN K ANTAGONIST ORAL ANTICOAGULANTS (NOACS) FOR ATRIAL FIBRILLATION: A UK BASED PROSPECTIVE MIXED METHODS STUDY.

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