PMCID: PMC3668194SEP was directly funded by the National Institute for Health Research
Cardiovascular Biomedical Research Unit at Barts. SN acknowledges support
from the Oxford NIHR Biomedical Research Centre and from the Oxford
British Heart Foundation Centre of Research Excellence. SP and PL are
funded by a BHF Senior Clinical Research fellowship. RC is supported by a
BHF Research Chair and acknowledges the support of the Oxford BHF Centre
for Research Excellence and the MRC and Wellcome Trust. PMM gratefully
acknowledges training fellowships supporting his laboratory from the
Wellcome Trust, GlaxoSmithKline and the Medical Research Council

A Hofman

A Jain

A Moran

AA Malayeri

AG Bertoni

AK Chung

AL Jefferson

Alistair A Young

BA Wasserman

BD Rosen

C Jenkins

David A Bluemke

E Castillo

E Dall’Armellina

Eike Nagel

F Sardi

Fabian Bamberg

Frank E Rademakers

GA Dore

H Bahrami

H Tandri

H Volzke

Jane M Francis

Jonathan Sellors

JR Romero

K Hegenscheid

K Nasir

KA Arntzen

KN Hor

M Backhaus

Matthias G Friedrich

MH Drazner

Paul Leeson

Paul M Matthews

R Macedo

Rory Collins

S Dass

S Natori

S Uribe

SK Mehta

SK Piechnik

SR Heckbert

Stefan Neubauer

Steffen E Petersen

Steve Garratt

Sven Plein

T Edvardsen

Tim Peakman

VM Ferreira

VR Fernandes

X Lu

Journal of Cardiovascular Magnetic Resonance

English

PubMed

UK Biobank is a prospective cohort study with 500,000 participants aged 40 to 69. Recently an enhanced imaging study received funding. Cardiovascular magnetic resonance (CMR) will be part of a multi-organ, multi-modality imaging visit in 3-4 dedicated UK Biobank imaging centres that will acquire and store imaging data from 100,000 participants (subject to successful piloting). In each of UK Biobank's dedicated bespoke imaging centres, it is proposed that 15-20 participants will undergo a 2 to 3 hour visit per day, seven days a week over a period of 5-6 years. The imaging modalities will include brain MRI at 3 Tesla, CMR and abdominal MRI at 1.5 Tesla, carotid ultrasound and DEXA scans using carefully selected protocols. We reviewed the rationale, challenges and proposed approaches for concise phenotyping using CMR on such a large scale. Here, we discuss the benefits of this imaging study and review existing and planned population based cardiovascular imaging in prospective cohort studies. We will evaluate the CMR protocol, feasibility, process optimisation and costs. Procedures for incidental findings, quality control and data processing and analysis are also presented. As is the case for all other data in the UK Biobank resource, this database of images and related information will be made available through UK Biobank's Access Procedures to researchers (irrespective of their country of origin and whether they are academic or commercial) for health-related research that is in the public interest

Petersen, Steffen E.

Matthews, Paul M.

Bamberg, Fabian

Bluemke, David A.

Francis, Jane M.

Friedrich, Matthias G.

Leeson, Paul

Nagel, Eike

Plein, Sven

Rademakers, Frank E.

Young, Alistair A.

Garratt, Steve

Peakman, Tim

Sellors, Jonathan

Collins, Rory

Neubauer, Stefan

Open Access LMU

Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches

Petersen, SE

Matthews, PM

Bamberg, F

Bluemke, DA

Francis, JM

Friedrich, MG

Leeson, P

Nagel, E

Plein, S

Rademakers, FE

Young, AA

Garratt, S

Peakman, T

Sellors, J

Collins, R

Oxford University Research Archive

Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches.

Crossref

Neubauer, S

Queen Mary Research Online

Alzheimer’s disease, autoimmunity and inflammation. The good, the bad and the ugly. Autoimmun Rev.

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Potentially relevant incidental findings on research whole-body MRI in the general adult population: frequencies and management. European radiolog.

Regional diastolic dysfunction in individuals with left ventricular hypertrophy measured by tagged magnetic resonance imaging–the multi-ethnic study of atherosclerosis (MESA). American heart journal.

Relation between central adiposity and cognitive function in the Maine-Syracuse Study: attenuation by physical activity. Ann Behav Med.

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Women have higher left ventricular ejection fractions than men independent of differences in left ventricular volume: the Dallas Heart Study. Circulation.

Oxford University Research Archive (ORA)

Universität München: Elektronischen Publikationen

UK Biobank is a prospective cohort study with 500,000 participants aged 40 to 69. Recently an enhanced imaging study received funding. Cardiovascular magnetic resonance (CMR) will be part of a multi-organ, multi-modality imaging visit in 3 – 4 dedicated UK Biobank imaging centres that will acquire and store imaging data from 100,000 participants (subject to successful piloting). In each of UK Biobank ’ s dedicated bespoke imaging centres, it is proposed that 15 – 20 participants will undergo a 2 to 3 hour visit per day, seven days a week over a period of 5 – 6 years. The imaging modalities will include brain MRI at 3 Tesla, CMR and abdominal MRI at 1.5 Tesla, carotid ultrasound and DEXA scans using carefully selected protocols. We reviewed the rationale, challenges and proposed approaches for concise phenotyping using CMR on such a large scale. Here, we discuss the benefits of this imaging study and review existing and planned population based cardiovascular imaging in prospective cohort studies. We will evaluate the CMR protocol, feasibility, process optimisation and costs. Procedures for incidental findings, quality control and data processing and analysis are also presented. As is the case for all other data in the UK Biobank resource, this database of images and related information will be made available through UK Biobank ’ s Access Procedures to researchers (irrespective of their country of origin and whether they are academic or commercial) for health-related research that is in the public interest

Spiral - Imperial College Digital Repository

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Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches

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