This work was supported by national funds through the Portuguese Foundation for Science and Technology under the scope of the project PTDC/EBB-BIO/114523/2009 and by the European Regional Development Fund (ERDF) through the Operational Competitiveness Programme “COMPETE” (FCOMP-01-0124-FEDER-014758). The authors are also thankful for the financial support of the Portuguese Foundation for Science and Technology under the strategic funding of UID/ BIO/04469/2013 unit and RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462) and the European Union under the Marie Curie Career Integration Grant SuprHApolymers (PCIG14-GA-2013-631871)

Azevedo, HS

Martins, IM

Reis, RL

ACS Chemical Biology

The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acschembio.5b00717. Table S1 shows the follow-up analysis on the subsequent applications of peptide sequences listed in Table 1 (PDF).The field of regenerative medicine has been gaining momentum steadily over the past few years. The emphasis in regenerative medicine is to use various in-vitro and in-vivo approaches that leverage on the intrinsic healing mechanisms of the body to treat patients with disabling injuries and chronic diseases such as diabetes, osteoarthritis, and degenerative disorders of the cardiovascular and central nervous system. Phage display has been successfully employed to identify peptide ligands for a wide variety of targets, ranging from relatively small molecules (enzymes, cell receptors) to inorganic, organic, and biological (tissues) materials. Over the last two decades, phage display technology has advanced tremendously and has become a powerful tool in the most varied fields of research, including biotechnology, materials science, cell biology, pharmacology, and diagnostics. The growing interest in and success of phage display libraries is largely due its incredible versatility and practical use. This review discusses the potential of phage display technology in biomaterials engineering for applications in regenerative medicine.This work was supported by national funds through the Portuguese Foundation for Science and Technology under the scope of the project PTDC/EBB-BIO/114523/2009 and by the European Regional Development Fund (ERDF) through the Operational Competitiveness Programme “COMPETE” (FCOMP-01-0124-FEDER-014758). The authors are also thankful for the ﬁnancial support of the Portuguese Foundation for Science and Technology under the strategic funding of UID/ BIO/04469/2013 unit and RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462) and the European Union under the Marie Curie Career Integration Grant SuprHApolymers (PCIG14-GA-2013-631871). We thank L. Kluskens, from the Center of Biological Engineering at the University of Minho (Portugal) for his expert opinion on phage display and valuable comments during the reading of the manuscript. We are also very grateful to A. Mata from the School of Engineering & Materials Science at Queen Mary University of London for his insightful comments and suggestions on the manuscript

Martins, Ivone M.

Reis, R. L.

Azevedo, Helena S.

Universidade do Minho: RepositoriUM

Phage display technology in biomaterials engineering: progress and opportunities for applications in regenerative medicine

Ivone M. Martins

Rui L. Reis

Helena S. Azevedo

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Phage Display Technology in Biomaterials Engineering: Progress and Opportunities for Applications in Regenerative Medicine

Queen Mary Research Online

http://repositorium.sdum.uminho.pt/bitstream/1822/43247/1/document_45180_1.pdf

Phage Display Technology in Biomaterials Engineering: Progress and Opportunities for Applications in Regenerative Medicine

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Universidade do Minho: RepositoriUM

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Queen Mary Research Online