NIH grant U01CA182940 (EGL, WDH, WMG, SKM, KC); NIH grants P50CA150964, U54CA163060 and P30CA43703 (WMG, JEW, AC); NIH grants UO1CA152756, P30CA015704, and U01CA086402 (SKM, YM, WMG); the DeGregorio Family and Price Family Foundation (WMG, EGL); and Barts Charity, London (KC)