A dataset on 25 projects that provided data on an internal monitoring evaluation of the Makerere University-Uganda Virus Research Institute Centre of Excellence for Infection and Immunity Research and Training (MUII-plus) research programme. The dataset contains 75 variables on projects adherence to the approved protocol, Standard Operating Procedures (SOPs), Good Clinical Practices (GCP) and Good Clinical Laboratory Practices (GCLP), other applicable regulatory requirements, study related training and presence of adequate facilities required for study related procedures