Unsafe abortion is an issue of public health concern and contributes significantly to maternal morbidity and mortality globally. Abortion evokes religious, moral, ethical, socio-cultural and medical concerns which mean it is highly stigmatized and this poses a threat to both providers and researchers. This study examined the challenges to providing safe abortion services from the perspective of health providers in Ghana. In-depth interviews were performed with obstetrician/gynaecologists, nurse-midwives and pharmacists (n = 36) in three (3) hospitals and five (5) health centres in the capital city in Ghana