BACKGROUND AND AIM: In this manuscript, fluoride releasing dental materials controlling demineralization in fixed orthodontic patients, and the current strategies to prevent white spots were evaluated. METHODS: General literature review was carried out in SciVerse ScienceDirect databases. The search strategy included the terms from Medical Subject Headings (MeSH) created by National Library of Medicine. RESULTS: 44 relevant studies were included and the respective data were extracted. Many studies showed new alternatives for the treatment of white spot lesions by the use of orthodontic appliances. CONCLUSION: Patients receiving fixed orthodontic treatment should be instructed in a proper brushing technique using a fluoride containing toothpaste, and high risk patients should be bonded with fluoride releasing agent. Additionally, it is recommended to apply fluoride varnish periodically during orthodontic treatment
