We present a quantitative analysis of recent data on the kinetics of ATP
hydrolysis, which has presented a puzzle regarding the load dependence of the
Michaelis constant. Within the framework of coarse grained two-state ratchet
models, our analysis not only explains the puzzling data, but provides a
modified Michaelis law, which could be useful as a guide for future
experiments.Comment: 4 pages, 3 eps figures, accepted for publication on Physical Review
Letter
