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research
Is there a potential of misuse for venlafaxine and bupropion?
Authors
Anderson
Augustin
+63 more
Baker
Baribeau
Bolden-Watson
Campagne
Carvalho
Chiappini
Chiappini
Chouinard
Cosci
Cutler
Deluca
Evans
Fava
Fava
Fountain
Francesconi
Groot
Harvey
Harvey
Hill
Hilliard
Holland
Hopper
Hu
Kantor
Kelly
Khurshid
Kim
Koga
Kotzalidis
Langguth
Lewin
Llorca
Maj
McCormick
Muth
Nelson
Orsolini
Parker
Phillips
Quaglio
Redrobe
Reeves
Renoir
Rettew
Rudolph
Sabljić
Schifano
Schifano
Shang
Shenouda
Sir
Stahl
Stahl
Stahl
Stall
Stassinos
Taylor
Vento
Weikop
Welsh
Wilson
Yoon
Publication date
1 January 2018
Publisher
'Frontiers Media SA'
Doi
Cite
Abstract
© 2018 Schifano and Chiappini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Objective: Traditionally, studies on the nonmedical use of pharmaceutical products have focused on controlled substances; e.g. opiates/opioids; and benzodiazepines. Although both bupropion and venlafaxine have been reported as being misused, only anecdotal reports have been made available so far. Hence, the European Monitoring Agency (EMA) Adverse Drug Reactions (ADRs), misuse/abuse/dependence and withdrawal, venlafaxine- and bupropion-related, database was here analyzed. Methods: All EMA spontaneous reports relating to venlafaxine (2005-2016) and bupropion (2003-2016) notifications were here analyzed, to provide a descriptive analysis by source, gender, age, and type of report. The UK-based, 2000-2016, Yellow Card Scheme pharmacovigilance database, bupropion and venlafaxine withdrawal reports were compared as well with those pertaining to fluoxetine and paroxetine. Results: Out of 20,720 (bupropion) and 47,516 (venlafaxine) total number of ADRs, some 2,232 (10.8%), and 4,071 (8.5%) misuse/abuse/dependence ADRs were respectively associated with bupropion and venlafaxine. Conversely, bupropion withdrawal-related ADRs were here reported in 299/20,720 (1.44%) cases and in 914/47,516 (1.92%) cases for venlafaxine. Overall, all bupropion and venlafaxine misuse-/abuse-/dependence- and withdrawal-ADRs were related to a respective number of 264 and 447 patients. According to the Proportional Reporting Ratio (PRR) computation, in comparison with venlafaxine bupropion resulted to be more frequently misused/abused (PRR: 1.50), but less frequently associated with both dependence (PRR: 0.92) and withdrawal (PRR: 0.77) issues. Yellow Card Scheme data suggested that paroxetine and venlafaxine, in comparison with fluoxetine and bupropion, were associated with higher number of withdrawal-related reports. Conclusions: The dopaminergic, stimulant-like, bupropion activities may be associated with its possible recreational value. Present data may confirm that the occurrence of a withdrawal syndrome may be a significant issue for venlafaxine-treated patients.Peer reviewedFinal Published versio
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