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research
Nitrates for the Management of Acute Heart Failure Syndromes, A Systematic Review
Authors
Mohamed Farag
Diana A Gorog
Ahmad Shoaib
Publication date
8 July 2016
Publisher
'SAGE Publications'
Doi
Cite
Abstract
© The Author(s) 2016Intravenous nitrates are widely used in the management of acute heart failure syndrome (AHFS) yet with lack of robust evidence to support their use. We therefore sought to analyze all randomized studies that evaluated the effects of nitrates on clinical outcomes in patients with AHFS. In total, 15 relevant trials comparing nitrates and alternative interventions in 1824 patients were identified. All but 3 were conducted before 1998. No trials demonstrated a beneficial effect on mortality, apart from 1 trial reporting a reduction in mortality, which was related to the time of treatment. Retrospective review suggests that there is a lack of data to draw any firm conclusions concerning the use of nitrates in patients with AHFS. More studies are needed to evaluate the safety and efficacy of these agents in the modern era of guideline-directed use of heart failure therapy.Peer reviewedFinal Accepted Versio
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info:doi/10.1177%2F10742484166...
Last time updated on 05/12/2020
University of Hertfordshire Research Archive
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oai:uhra.herts.ac.uk:2299/2132...
Last time updated on 09/03/2020