D. Ganessunker

Dunsford BR

Filipe MI

Foitzik T

H. R. Gaskins

J. E. Conour

K. A. Tappenden

Lev R.

Nieuw Amerongen AV

S. M. Donovan

Schmitz H

Vezina SA

Total parenteral nutrition (TPN) impairs small intestine development and is associated with barrier failure, inflammation, and acidomucin goblet cell expansion in neonatal piglets. We examined the relationship between intestinal goblet cell expansion and molecular and cellular indices of inflammation in neonatal piglets receiving TPN, 80% parenteral + 20% enteral nutrition (PEN), or 100% enteral nutrition (control) for 3 or 7 days. Epithelial permeability, T cell numbers, TNF-α and IFN-γ mRNA expression, and epithelial proliferation and apoptosis were compared with goblet cell numbers over time. Epithelial permeability was similar to control in the TPN and PEN jejunum at day 3 but increased in the TPN jejunum by day 7. By day 3, intestinal T cell numbers were increased in TPN but not in PEN piglets. However, goblet cell expansion was established by day 3 in both the TPN and PEN ileum. Neither TNF-α nor IFN-γ mRNA expression in the TPN and PEN ileum correlated with goblet cell expansion. Thus goblet cell expansion occurred independently of overt inflammation but in association with parenteral feeding. These data support the hypothesis that goblet cell expansion represents an initial defense triggered by reduced epithelial renewal to prevent intestinal barrier failure.</jats:p

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AJP Gastrointestinal and Liver Physiology

Acidomucin goblet cell expansion induced by parenteral nutrition in the small intestine of piglets

Acidomucin goblet cell expansion induced by parenteral nutrition in the small intestine of piglets

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