Physical rehabilitation therapy is indispensable for treating neurological disabilities. The use of robotic devices for rehabilitation holds high promise, since these devices can bear the physical burden of rehabilitation exercises during intense therapy sessions, while therapists are employed as decision makers. Robot-assisted rehabilitation devices are advantageous as they can be applied to patients with all levels of impairment, allow for easy tuning of the duration and intensity of therapies and enable customized, interactive treatment protocols. Moreover, since robotic devices are particularly good at repetitive tasks, rehabilitation robots can decrease the physical burden on therapists and enable a single therapist to supervise multiple patients simultaneously; hence, help to lower cost of therapies. While the intensity and quality of manually delivered therapies depend on the skill and fatigue level of therapists, high-intensity robotic therapies can always be delivered with high accuracy. Thanks to their integrated sensors, robotic devices can gather measurements throughout therapies, enable quantitative tracking of patient progress and development of evidence-based personalized rehabilitation programs. In this dissertation, we present the design, control, characterization and user evaluations of AssistOn-Arm, a powered, self-aligning exoskeleton for robotassisted upper-extremity rehabilitation. AssistOn-Arm is designed as a passive back-driveable impedance-type robot such that patients/therapists can move the device transparently, without much interference of the device dynamics on natural movements. Thanks to its novel kinematics and mechanically transparent design, AssistOn-Arm can passively self-align its joint axes to provide an ideal match between human joint axes and the exoskeleton axes, guaranteeing ergonomic movements and comfort throughout physical therapies. The self-aligning property of AssistOn-Arm not only increases the usable range of motion for robot-assisted upper-extremity exercises to cover almost the whole human arm workspace, but also enables the delivery of glenohumeral mobilization (scapular elevation/depression and protraction/retraction) and scapular stabilization exercises, extending the type of therapies that can be administered using upper-extremity exoskeletons. Furthermore, the self-alignment property of AssistOn-Arm signi cantly shortens the setup time required to attach a patient to the exoskeleton. As an impedance-type device with high passive back-driveability, AssistOn- Arm can be force controlled without the need of force sensors; hence, high delity interaction control performance can be achieved with open-loop impedance control. This control architecture not only simpli es implementation, but also enhances safety (coupled stability robustness), since open-loop force control does not su er from the fundamental bandwidth and stability limitations of force-feedback. Experimental characterizations and user studies with healthy volunteers con- rm the transparency, range of motion, and control performance of AssistOn- Ar
