Charmed and beauty hadrons in matter are discussed within a unitarized coupled-channel model consistent with heavy-quark spin symmetry. We analyse the formation of D-mesic states as well as the propagation of charmed and beauty hadrons in heavy-ion collisions from LHC to FAIR energies.Charmed and beauty hadrons in matter are discussed within a unitarized coupled-channel model consistent with heavy-quark spin symmetry. We analyse the formation of D-mesic states as well as the propagation of charmed and beauty hadrons in heavy-ion collisions from LHC to FAIR energies