Membrane models proved its uniqueness as a tool for biophysics studies at single molecule level. Despite
impressive progress in the field of biomimetic membrane models, there are serious challenges limiting
their wider use in biological application, for example their stability and ability for communication with
different environment. This thesis described the development and uses of artificial membrane for
biophysical applications. The initial focus was on the investigation and design of a new membrane model
platform that mimics biological cell and tissues. In the first study we built a model membrane platform by
encapsulating one of membrane model called Droplet Interface Bilayer in hydrogel and we test the
function ability of this system by incorporating pore forming proteins. In the second study we characterize
amyloid peptides oligomers behavior using planar lipid technique. In the final study of this thesis we
designed and construct membrane nanomachine from DNA which it produce nanomechanical motion and
transport across the membranestatus: publishe