Saxena, Anshul

Veledar, Emir

English

Scholarly Commons@Baptist Health South Florida

Baptist Health South Florida Scholarly Commons @ Baptist Health South Florida All Publications 2019 Abstract 400.14: Application of Hierarchical Cluster Analysis to Study the Relationships Among CHADS2, CHA2DS2-Vasc, and Five Cardiac Risk Factors Scores (RFS) in Predicting Risk of Stroke Anshul Saxena Baptist Health South Florida, anshuls@baptisthealth.net Emir Veledar Baptist Health South Florida, emirv@baptisthealth.net Follow this and additional works at: https://scholarlycommons.baptisthealth.net/se-all-publications Citation JACC Cardiovascular Interventions (2019) 12(4 Suppl 5):S38 This Article -- Open Access is brought to you for free and open access by Scholarly Commons @ Baptist Health South Florida. It has been accepted for inclusion in All Publications by an authorized administrator of Scholarly Commons @ Baptist Health South Florida. For more information, please contact Carrief@baptisthealth.net. vascular wall in both groups. Immediately after harvesting, we foundthe mRNA signal. After 15 min to 1 hour, the expression wasdownregulated.CONCLUSION Based on our analyses, we can conclude that in case ofconventional technique, less damage of SV was observed than in thecase of endoscopic harvesting. All other parameters showed the sameresults in both groups.400.13Premedication with Steroids and Short-Term and Long-TermRenal Outcomes After Coronary and Peripheral Angiographyand InterventionWendy Bottinor,1 Raveen Chawla,1 Jeremy Turlington,1 Kalpesh Patel,1Peter Danyi,2 Robert A. Perera,1 Ion S. Jovin11Virginia Commonwealth University, Richmond, VA; 2Salem VAMC,Salem, VABACKGROUND Limited data exist regarding the outcomes after cor-onary and peripheral angiography and intervention in patients with ahistory of contrast dye allergy who are premedicated with steroids.METHODS We studied 4367 patients undergoing peripheral or coro-nary angiography and percutaneous coronary or endovascular inter-vention at a Veterans’ Affairs Medical Center. We assessed short-termand long-term outcomes: contrast-induced nephropathy, renaldysfunction/contrast-induced nephropathy at 3 months, chronic kid-ney failure necessitating dialysis, and mortality in patients pretreatedand not pretreated with steroids.RESULTS The study population was predominantly male (98%)and white (65%) with a mean age of 66 years. Of the total patientpopulation, 260 (5.9%) of the total subjects had either a contrastor a seafood/shellfish allergy and were pretreated with steroids.Of the 4367 subjects, 1962 (45%) had repeat creatinine values at 3days, and 3100 (70%) had repeat creatinine values at 3 months.Overall 3 (2.5%) patients in the allergy group and 85 (4%) patientsin the non-allergy group developed contrast-induced nephropathyat 3 days (P¼0.39). The proportion of patients with nephropathyat 3 months and of patients who were started on dialysis after 5years was not significantly different between the 2 groups. After 5years, 40 (15.4%) patients in the allergy group and 812 (19.8%)patients in the non-allergy group had died (P¼0.09). Afteradjustment for baseline comorbidities, there was a significant in-verse association between dye allergy/steroid premedication anddeath at 5 years (odds ratio 0.72; 95% confidence interval 0.53-1;P¼0.049).CONCLUSIONS In this cohort of US veterans, pretreatment with ste-roids was not associated with the development of renal dysfunction orthe initiation of dialysis. The association between dye allergy, steroidspretreatment, and mortality needs to be validated in larger cohorts.400.14Application of Hierarchical Cluster Analysis to Study theRelationships Among CHADS2, CHA2DS2-Vasc, and FiveCardiac Risk Factors Scores (RFS) in Predicting Risk ofStrokeEnisa Ademovic,1 Anshul Saxena,2 Semra Cavaljuga,1 Emir Veledar21Univ Hosp, Sarajevo, Bosnia and Herzegovina; 2Baptist Health SouthFlorida, Coral Gables, FLOBJECTIVE Various risk calculators for stroke may not be practical inplanning prevention as these mostly include non-modifiable factors.We compared 2 popular risk scores for stroke and 5 risk factors scores(RFS) meant for cardiovascular disease (CVD) with modifiable factors.We believe that identifying and managing modifiable factors fromother scores may help in better stroke prevention planning.METHODS We utilized data gathered from patients admitted to Uni-versity Hospital in Sarajevo between 2014 and 2016. Five RFS, namely,10-year Framingham CHD, QRISK 2, AHA/ACC ASCVD risk, Framing-ham ATP III, and EU SCORE, along with CHADS2 and CHA2DS2-VAScscores were calculated. We entered 5 RFS as dimensions in a hierar-chical cluster analysis to group people based on their risk of devel-oping CVD and compared cluster membership cutoffs for CHADS2 andCHA2DS2-VASc scores.RESULTS There were 1277 patients in this study, and a majority (65%)were women. The mean (SD) age of the sample was 56.2 (11.4) years.Values for each score within each cluster are presented in Table 1.Obtained clusters were homogenous and were able to classify patientsinto 4 clusters, ordered from lowest to highest risk. Cluster 1 con-tained patients with lowest mean scores, and cluster 4 with highestmean scores. Stroke and CVD risk scores pointed in the same directionand could be used in complimentary way.CONCLUSION This novel method produced good estimates of a pa-tient’s risk of developing stroke by combining several scores. SinceCHADS2 and CHA2DS2-VASc scores are mostly comprised of non-modifiable risk factors, other CVD risk scores may provide more in-sights into stroke risk management. Correctly identifying patientswho truly have a low risk of developing stroke may help a practi-tioner’s decision about administration of anticoagulants; these couldbe safely withheld among those who are at greater risk of harm thanbenefit.S38 J A C C : C A R D I O V A S C U L A R I N T E R V E N T I O N S , V O L . 1 2 , N O . 4 , S U P P L S , 2 0 1 9SCIENCEJACC. Cardiovascular interventionsPUBLICATION TYPE: e-Journal Digital SharingSpecial terms : DISPLAYING IN A PRESENTATION TO AN EXTERNAL AUDIENCE IS GRANTED FOR THIS CONTENT BUT ONLY FOR AUDIENCES THAT ARE LESS THAN 100 ATTENDEES.Your organization has obtained rights for you to copy and share this title in electronic form.Examples includeThe license cannot be used to create a library or collection intended to substantially replace the need to take a subscription or purchase a particular Work.Special terms : DISPLAYING IN A PRESENTATION TO AN EXTERNAL AUDIENCE IS GRANTED FOR THIS CONTENT BUT ONLY FOR AUDIENCES THAT ARE LESS THAN 100 ATTENDEES.ISSN: 1876-7605Date: 2008 - PresentPublisher: Elsevier ScienceLanguage: EnglishCountry: United States of AmericaURL: http://www.sciencedirect.com/science/journal/19368798Licensee:Organization: Baptist Health South FloridaDate/Time: 31 Jan 2020 10:09This permission type is covered.• Emailing a copy to my co-workers.• Storing a copy on an internal shared network.• Storing a copy on your local hard drive.• Displaying in a presentation to co-workers.• Distributing in a PowerPoint presentation to co-workers.• Submitting an electronic copy to regulatory authorities.Page 1 of 1RightFind Search1/31/2020https://rightfind.copyright.com/rs-ui-web/search

Abstract 400.14: Application of Hierarchical Cluster Analysis to Study the Relationships Among CHADS2, CHA2DS2-Vasc, and Five Cardiac Risk Factors Scores (RFS) in Predicting Risk of Stroke

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Abstract 400.14: Application of Hierarchical Cluster Analysis to Study the Relationships Among CHADS2, CHA2DS2-Vasc, and Five Cardiac Risk Factors Scores (RFS) in Predicting Risk of Stroke

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