Koomhin, Phanit

Kumanee, Nattawan

Na-Ek, Prasit

Palipoch, Sarawoot

Phenwan, Tharin

Poonsawat, Wasinee

Punsawad, Chuchard

Sattayakhom, Apsorn

English

As Thailand is entering an aging society, one of the important chronic diseases of Thai elderly population is dementia including Alzheimer's disease (AD). AD is a heritable and the most common type of senile dementia. In addition to the major genetic determinant of AD, the Apolipoprotein E (ApoE) genetic variants have been associated. The human ApoE gene is derived from the polymorphic combination of ApoE rs429358 and rs7412 that results in ApoE-ε2, ApoE-ε3 and ApoE-ε4 isoforms. The associations between ApoE genetic variants and the risk of AD have been demonstrated in numerous epidemiological studies in Caucasians but very less established in Asians, especially in Southern Thai population. We hereby assessed the distributions of these ApoE variants on aging population with cognitive impairment/dementia diagnosed in Nakhon Si Thammarat as a preliminary study for further study on the effects of these variants in all cause dementia among population

University of Dundee Online Publications

There is no subject was detected with ApoE rs7412 T/T genotype and ApoE rs429358 C/C genotype which represent ApoE-ε2 and ApoE-ε4 variants of ApoE that are associated with the decreased and increased risk of AD compared with the individual carrying the more common ε3 allele, respectively.IntroductionApolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai EthnicityApsorn SATTAYAKHOM1, Tharin PHENWAN2, Sarawoot PALIPOCH2, Chuchard PUNSAWAD2, Prasit NA-EK2, Wasinee POONSAWAT3, Nattawan KUMANEE3, Phanit KOOMHIN2,3*1 School of Allied Health Sciences, Walailak University, Nakhonsithammarat, Thailand2 School of Medicine, Walailak University, Nakhonsithammarat, Thailand3 Research Institute for Health Sciences, Walailak University, Nakhonsithammarat, Thailand*Corresponding author: Phanit KOOMHIN/ E-mail: phanit.ko@mail.wu.ac.thMethodResult ConclusionInitially, there were a total of 71 aging participants in the present study. Forty participants  were included for data analysis due to the cognitive status evaluation criteria. As in a table , the mean age of the participants was  77.18±8.27 years;  20 and  80 %  of  the subjects were male and female, respectively. Within the 40 subjects, 32 subjects were detected with ApoE rs429358 T/T genotype (accounting for 80% of all subjects). Only 8 subjects were detected with ApoE rs429358 C/T genotype (accounting for 20% of all subjects). Among these, 35 subjects were of the ApoE rs7412 C/C genotype (accounting for 87.5% of all subjects) and 5 subjects were of the ApoE rs7412 C/T genotype (accounting for 12.5% of all subjects).These results demonstrated that the ApoE rs429358 and rs7412 genotype C/T is accounting for 20% and 12.5% , respectively. There is no subject was detected with ApoE rs7412 T/T genotype and ApoE rs429358 C/C genotype which represent ApoE-ε2 and ApoE-ε4 variants of ApoE that are associated with the decreased and increased risk of AD compared with the individual carrying the more common ε3 allele, respectively. As Thailand is entering an aging society, one of the important chronic diseases of Thai elderly population is dementia including Alzheimer's disease (AD). AD is a heritable and the most common type of senile dementia. In addition to the major genetic determinant of AD, the Apolipoprotein E (ApoE) genetic variants have been associated. The human ApoE gene is derived from the polymorphic combination of ApoE rs429358 and rs7412 that results in ApoE-ε2, ApoE-ε3 and ApoE-ε4 isoforms. The associations between ApoE genetic variants and the risk of AD have been demonstrated in numerous epidemiological studies in Caucasians but very less established in Asians, especially in Southern Thai population. We hereby assessed the distributions of these ApoEvariants on aging population with cognitive impairment/dementia  diagnosed in Nakhon Si Thammarat  as a preliminary study for further study on the effects of these variants in all cause dementia among population. • Senanarong V, Harnphadungkit K, Poungvarin N, et al. The Dementia and Disability Project in Thai Elderly: rational, design, methodology and early results. BMC Neurol. 2013;13:3. Published 2013 Jan 10. doi:10.1186/1471-2377-13-3.• Zhen J, Huang X, Van Halm-Lutterodt N, Dong S, Ma W, Xiao R, Yuan L. ApoE rs429358 and rs7412 Polymorphism and Gender Differences of Serum Lipid Profile and Cognition in Aging Chinese Population. Front Aging Neurosci. 2017 Aug 2;9:248. ReferencesGrant supported by Division of Planning and Strategy Walailak UniversityAcknowledgement

Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity

https://discovery.dundee.ac.uk/files/38163851/Poster_Dementia_Aj.aom_26.03.2019.pdf

Apolipoprotein E Gene Polymorphism in Aging Population with Dementia in Nakhon Si Thammarat: A Preliminary Study of Southern Thai Ethnicity

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