Context: COVID-19 is a new pandemic in the world and data in the various aspect of this disease are evolving. In this review, the authors try to cover different aspects of clinical manifestations and the natural course of the disease. Evidence acquisition: For data gathering, the authors searched through MEDLINE, Cochrane library, google scholar and Scopus. The key phrases for search were "clinical presentation of COVID-19", "clinical features of COVID-19", "natural course of COVID-19", "neurologic manifestation of COVID-19", "cardiovascular manifestation of COVID-19" and "gastrointestinal manifestation of COVID-19". Results: After screening of titles and abstracts, the authors finally enrolled 55 articles. Then the full texts of the selected articles were read carefully to determine eligibility and extracting relevant information. Conclusion: The most common presentations of COVID-19 patients were fever, non-producing cough and dyspnea but a considerable amount of patients may seek heath care without these complaints. Asymptomatic patients and patients with only gastrointestinal and neurologic symptoms remain a significant challenge for medical practitioners
