BOSSO, ANTONELLA

CAZZOLA, MARTINA

CHUEN HOW, NG

FERRARIS, SARA

GUAITA, MASSIMO

SPRIANO, SILVIA

TAMBASCO, PAULO

VERNE', ENRICA

ÖRLYGSSON, GISSUR

English

SILVIA SPRIANO

MARTINA CAZZOLA

SARA FERRARIS

ENRICA VERNE’

ANTONELLA BOSSO

MASSIMO GUAITA

GISSUR ÖRLYGSSON

NG CHUEN HOW

PAULO TAMBASCO

PORTO@iris (Publications Open Repository TOrino - Politecnico di Torino)

04 August 2020POLITECNICO DI TORINORepository ISTITUZIONALEGRAFTING OF POLYPHENOLS FROM GRAPE POMACE TO IMPLANTABLE BIOMATERIALS: A CHEMICAL ANDBIOLOGICAL CHARACTERIZATION / SPRIANO, SILVIA; CAZZOLA, MARTINA; FERRARIS, SARA; VERNE', ENRICA;BOSSO, ANTONELLA; GUAITA, MASSIMO; ÖRLYGSSON, GISSUR; CHUEN HOW, NG; TAMBASCO, PAULO. -ELETTRONICO. - (2019). ((Intervento presentato al convegno 13th World Congress on Polyphenols Applicationstenutosi a Malta nel 30/09/2019.OriginalGRAFTING OF POLYPHENOLS FROM GRAPE POMACE TO IMPLANTABLE BIOMATERIALS: ACHEMICAL AND BIOLOGICAL CHARACTERIZATIONPublisher:PublishedDOI:Terms of use:openAccessPublisher copyright(Article begins on next page)This article is made available under terms and conditions as specified in the  corresponding bibliographic description inthe repositoryAvailability:This version is available at: 11583/2828532 since: 2020-05-22T11:53:15ZISANHGRAFTING OF POLYPHENOLS FROM GRAPE POMACE TO IMPLANTABLE BIOMATERIALS: A CHEMICAL AND BIOLOGICAL CHARACTERIZATION SILVIA SPRIANO1, MARTINA CAZZOLA1, SARA FERRARIS1, ENRICA VERNE’1, ANTONELLA BOSSO2, MASSIMO GUAITA2, GISSUR ÖRLYGSSON3, NG CHUEN HOW4, PAULO TAMBASCO5  1 Politecnico di Torino -ITALY 2 CREA, CNR- ITALY 3 ICI - ICELAND 4 GENIS - ICELAND 5 University of Sao Paulo - BRAZIL  Silvia.spriano@polito.it  Introduction: Objective of research is exploitation of the great potential benefits of polyphenols for enhancing mineralization and anticancer ability of bioactive materials for bone implants (titanium alloys, bioactive glasses and hydroxyapatite).  Materials and Methods: Polyphenols were extracted from grape pomace (GPH). A specific protocol for surface functionalization with GPH was developed case by case considering the different surface chemistry of the substrates. A characterization protocol suitable for all the materials was defined (fluorescent microscopy, Folin & Ciocalteu test applied both to GPH solutions and to surface functionalized samples, DPPH, contact angle, zeta potential titration measurements, bioactivity by soaking in Simulated Body Fluid, HPLC). Sterilization was performed through gamma irradiation. Cell cultures finalized to evaluation of mineralization and anticancer ability of GPH solutions, as well as of functionalized and control hydroxyapatite surfaces were performed. Results & Conclusions: Surface grafting of GPH was positively realized on all the substrates even if in different amount; grafted GPH maintain redox and scavenger activity (even after gamma sterilization), while bioactivity of the substrates is preserved. As assumed, benefits of GPH can be coupled to bioactive substrates. Cytocompatiblity, effective mineralization and antitumoral activity of GPH solutions with different concentration and of functionalized surfaces is discussed. 

GRAFTING OF POLYPHENOLS FROM GRAPE POMACE TO IMPLANTABLE BIOMATERIALS: A CHEMICAL AND BIOLOGICAL CHARACTERIZATION

https://iris.polito.it/retrieve/handle/11583/2828532/367336/GRAFTING%20OF%20POLYPHENOLS%20FROM%20GRAPE%20POMACE%20TO%20IMPLANTABLE%20BIOMATERIALS.pdf

GRAFTING OF POLYPHENOLS FROM GRAPE POMACE TO IMPLANTABLE BIOMATERIALS: A CHEMICAL AND BIOLOGICAL CHARACTERIZATION

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