Повторная трансректальная биопсия предстательной железы у пациентов с простатической интраэпителиальной неоплазией высокой степени: сроки и особенности проведения
Purpose. The aim of our study was to define optimal time and technique of repeat transrectal prostate biopsy in patients with high grade prostatic intraepithelial neoplasia.Materials and Methods. A total of 277 men with high grade prostatic intraepithelial neoplasia regardless of changes in serum prostate specific antigen (PSA) or digital rectal examination findings underwent follow up biopsy in 8 months (range 1—12 months) after diagnosis. All men had at least 12 (12—18) biopsy cores taken at the time of diagnosis.Results. Prostate cancer was found in 29,2% cases (81 of 277 patiens) after the second biopsy and in 2,9 % (1 of 35) cases after the third biopsy. The highest detection rate was found using 14 and 16 core biopsy schemes 12 and 6 months after the first biopsy.Conclusions. Our findings support the concept that high grade prostatic intraepithelial neoplasia is a precursor to prostate cancer and that repeat biopsy at a delayed interval is recommended regardless of changes in PSA.
