Open Access via the Karger Agreement This work was funded in part by Wellcome Trust Grant number 0934847/Z/10/Z.Peer reviewedPublisher PD

Cao, Huan

Mathur, Abhinav

Mclean, Mairi H.

Vickers, Mark A.

Digestive Diseases

English

Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders.Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management.Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.</p

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