Heligmosomoides polygyrus (formerly known as Nematospiroides dubius, and also referred to by some as H. bakeri) is a gastrointestinal
helminth that employs multiple immunomodulatory mechanisms to establish chronic infection in mice and closely resembles prevalent human
helminth infections. H. polygyrus has been studied extensively in the field of helminth-derived immune regulation and has been found to potently
suppress experimental models of allergy and autoimmunity (both with active infection and isolated secreted products). The protocol described in
this paper outlines management of the H. polygyrus life cycle for consistent production of L3 larvae, recovery of adult parasites, and collection of
their excretory-secretory products (HES)