Many applications in offshore engineering, such as floating or jacket-founded wind turbines or wave energy converters, require a significant uplift capacity of their foundations to be kept in place. Straight-shafted or suction piles in sands have a limited uplift capacity as they resist by friction only. In contrast, screw piles or screw anchors are a promising solution which provides a similar capacity to plate anchors and does not generate disturbance for marine mammals (e.g. from pile driving operations). The optimisation of the screw pile design does not rely only on the geotechnical assessment of the uplift capacity based on soil strength, but also on operational (installation requirements) and structural (helix bending, core section stress, limiting steel plate thick-ness) constraints. This paper develops a methodology for the design optimisation of screw piles under pure ten-sion in sand, incorporating all of these constraints, based on simplified analytical or semi-analytical approaches. The results show that the uplift capacity provided by an optimised screw pile is able to meet the needs of the offshore industry, across a range of soil densities and different applications (jacket foundation pile or tension leg platform anchor), providing that adequate installation plant could be dev