Akbar, Tahira

Chalmers, John

Colhoun, Helen M.

Lindsay, Robert S.

Livingstone, Shona J.

Looker, Helen C.

McGurnaghan, Stuart

McKnight, John A.

Palmer, Colin N. A.

Patrick, Alan W.

Pearson, Donald W. M.

Petrie, John R.

Walker, James

Palmer, Colin N.A.

Petrie, John

Pearson, Donald W.M.

Enlighten

English

Cohort Profile: Scottish Diabetes Research Network Type 1 Bioresource Study (SDRNT1BIO)

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Cohort Profile:Scottish Diabetes Research Network Type 1 Bioresource Study (SDRNT1BIO)

Tahira Akbar

Stuart McGurnaghan

Colin N.A. Palmer

Shona J. Livingstone

John Petrie

John Chalmers

Robert S. Lindsay

John A. McKnight

Donald W.M. Pearson

Alan W. Patrick

James Walker

Helen C. Looker

Helen M. Colhoun

Crossref

International Journal of Epidemiology

Enlighten: Publications

Looker, Helen

University of Dundee Online Publications

Palmer, Colin N A

McKnight, John

Colhoun, Helen

Edinburgh Research Explorer

Scottish Diabetes Research Network Type 1 Bioresource Study (SDRNT1BIO)

                                                                    University of DundeeCohort ProfileAkbar, Tahira; McGurnaghan, Stuart; Palmer, Colin N. A.; Livingstone, Shona J.; Petrie, JohnR.; Chalmers, JohnPublished in:International Journal of EpidemiologyDOI:10.1093/ije/dyw152Publication date:2017Document VersionPeer reviewed versionLink to publication in Discovery Research PortalCitation for published version (APA):Akbar, T., McGurnaghan, S., Palmer, C. N. A., Livingstone, S. J., Petrie, J. R., Chalmers, J., ... Colhoun, H. M.(2017). Cohort Profile: Scottish Diabetes Research Network Type 1 Bioresource Study (SDRNT1BIO).International Journal of Epidemiology, 46(3), 796-796i. https://doi.org/10.1093/ije/dyw152General rightsCopyright and moral rights for the publications made accessible in Discovery Research Portal are retained by the authors and/or othercopyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated withthese rights. • Users may download and print one copy of any publication from Discovery Research Portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain. • You may freely distribute the URL identifying the publication in the public portal.Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Download date: 19. Oct. 2019  Page 1 of 2 Pocket Profile for SDRNT1BIO  Title:  Cohort Profile: Scottish Diabetes Research Network Type 1 Bioresource Study (SDRNT1BIO)  Authors:  Tahira Akbar1, Stuart McGurnaghan1, Colin NA Palmer2, Shona J Livingstone3, John Petrie4, John Chalmers5, Robert S Lindsay6, John A McKnight7, Donald WM Pearson8, Alan W Patrick9, James Walker10, Helen C Looker3, Helen M Colhoun1,11  Cite this as:  The full version of this profile is available at IJE online and should be used when citing this profile.  Corresponding author:  Helen Colhoun; Helen.Colhoun@igmm.ed.ac.uk Complete author list is available in the full online version of the profile.  Keywords:  SDRNT1BIO, Type 1 Diabetes, Cohort Profile  Cohort purpose:  Type 1 diabetes (T1DM) causes substantial morbidity and loss of life expectancy from both acute metabolic complications and chronic complications.  The causal pathways of T1DM and its complications are only partially understood.  The Scottish Diabetes Research Network Type 1 Bioresource (SDRNT1BIO) is a collection of biosamples and data from adults with T1DM, Latent Autoimmune Diabetes of Adults (LADA) and Maturity Onset Diabetes of the Young (MODY) resident in Scotland.  It was established: to facilitate research into the genetic determinants of T1DM and its related complications; to enable discovery of predictive and surrogate biomarkers of complications yielding insight into pathogenesis; to enable stratification of apparent T1DM into monogenic and polygenic diabetes; and to discover environmental determinants of T1DM.  The ultimate aim is to drive forward the prevention of T1DM and its complications.   Cohort Basics:  Between 2010 and 2013, 6,127 participants aged 16 years and older with a clinical diagnosis of T1DM, MODY, or LADA were recruited.  They comprised consecutive attendees at routine hospital and primary care annual diabetes review visits in 10 of the 13 NHS Board areas in Scotland.  A questionnaire was completed, physical measurements made and samples stored.  Participants gave consent for follow-up in person (93%) and through their electronic health care records (100%).  They are representative of the total adult population with T1DM in Scotland in their clinical history and clinical and demographic characteristics.   Follow-up and attrition: Prospective data linkage will also provide follow-up data and a process of prospectively collecting serial samples using spare blood from clinical encounters has been established.  Design and Measures:  The SDRNT1BIO is a prospective cohort study. The baseline data set comprises biological samples including serum, plasma, whole blood and urine; physical measurements including anthropometry, bioimpedance, and blood pressure; and questionnaire data including sociodemographics, details of diabetes diagnosis and treatment, history of complications, and lifestyle assessment e.g. physical activity, smoking and alcohol.  Linkage to extensive retrospective and prospective e-health record data has   Page 2 of 2 captured all hospital admissions, annual diabetes clinical reviews, laboratory data, retinopathy screening, renal replacement register data, prescribing and death data.  Unique features:  The SDRNT1BIO is one of the largest and most comprehensive collections of biomaterials and data from people with T1DM worldwide and 93% of participants have consented to future re-contact for additional studies.  Unique features include harnessing the common health care identifier used in all health records in Scotland to collect comprehensive retrospective and prospective data at minimal cost and automated capture of future blood samples from routine clinical encounters.   Reasons to be cautious:  Only a subset of SDRNT1BIO participants have follow-up biosamples as yet though almost all have follow-up data.  Collaboration and data access:  Data are accessed through supported collaboration with the study investigators.  Interested collaborators should contact the study coordinator in the first instance (Helen.Colhoun@igmm.ed.ac.uk).  Funding and competing interests:  The Chief Scientist Office and Diabetes UK provided core funding and in-kind contribution from Scottish Diabetes Research Network to facilitate recruitment.  H.M.C.:  research support and honorarium and member of advisory panels and speaker’s bureaus for Sanofi Aventis, Regeneron, and Eli Lilly; Advisory Panel for Novartis Pharmaceuticals; research support from Roche Pharmaceuticals, Pfizer Inc., Boehringer Ingelheim, and AstraZeneca LP; shareholder of Roche Pharmaceuticals and Bayer.  R.S.L.: member of advisory panels for Novo Nordisk and Eli Lilly; research support from Novo Nordisk, Eli Lilly, and GlaxoSmithKline.  The other authors declare no conflicts of interest.  Author affiliations: 1 Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK, 2Cardiovascular and Diabetes Medicine, University of Dundee, Dundee, UK, 3Diabetes Epidemiology Unit, University of Dundee, Dundee, UK, 4Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK, 5Victoria Hospital, National Health Service (NHS) Fife, Kirkcaldy, UK, 6British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK, 7Western General Hospital, NHS Lothian, Edinburgh, UK, 8JJR Macleod Centre for Diabetes, Endocrinology and Metabolism, Aberdeen Royal Infirmary, Aberdeen, UK, 9Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK, 10St John’s Hospital, NHS Lothian, Livingston, UK and 11Department of Public Health, NHS Fife, Kirkcaldy, UK  

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Cohort Profile:Scottish Diabetes Research Network Type 1 Bioresource Study (SDRNT1BIO)

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