Balleine

Bandura

Belova

Bhanji

Botvinick

Buckner

Buhle

Cavanna

Chua

Cieslik

Connolly

Deci

Enriquez-Geppert

Epstein

First

Fitzgerald

Griffin

Haber

Howlett

Keedwell

Kumar

Leotti

Luciano

Maier

Murty

Namburi

Navrady

Ochsner

Olesen

Ouden den

O’Doherty

Ravizza

Rodin

Ruby

Rutledge

Ryan

Smoski

Steele

Tabibnia

Tricomi

Vogeley

Wang

Whitton

Yang

Biological Psychiatry Cognitive Neuroscience and Neuroimaging

Crossref

The Neurobiology of Personal Control During Reward Learning and Its Relationship to Mood

Background: The majority of reward learning neuroimaging studies have not focused on the motivational aspects of behavior, such as the inherent value placed on choice itself. The experience and affective value of personal control may have particular relevance for psychiatric disorders, including depression.Methods: We adapted a functional magnetic resonance imaging reward task that probed the value placed on exerting control over one's decisions, termed choice value, in 122 healthy participants. We examined activation associated with choice value; personally chosen versus passively received rewards; and reinforcement learning metrics, such as prediction error. Relationships were tested between measures of motivational orientation (categorized as autonomy, control, and impersonal) and subclinical depressive symptoms.Results: Anticipating personal choice activated left insula, cingulate, right inferior frontal cortex, and ventral striatum (p familywise error–corrected &lt;.05). Ventral striatal activations to choice were diminished in participants with subclinical depressive symptoms. Personally chosen rewards were associated with greater activation of the insula and inferior frontal gyrus, cingulate cortex, hippocampus, thalamus, and substantia nigra compared with rewards that were passively received. In participants who felt they had little control over their own behavior (impersonal orientation), prediction error signals in nucleus accumbens were stronger during passive trials.Conclusions: Previous findings regarding personal choice have been verified and advanced through the use of both reinforcement learning models and correlations with psychopathology. Personal choice has an impact on the extended reward network, potentially allowing these clinically important areas to be addressed in ways more relevant to personality styles, self-esteem, and symptoms such as motivational anhedonia. </p

Romaniuk, Liana

Sandu, Anca-Larisa

Waiter, Gordon D.

McNeil, Christopher J.

Xueyi, Shen

Harris, Matthew A.

MacFarlane, Jennifer A.

Lawrie, Stephen M.

Deary, Ian J.

Murray, Alison D.

Delgado, Mauricio R.

Steele, J. Douglas

McIntosh, Andrew M.

Whalley, Heather C.

Discovery Research Portal

English

Background The majority of reward learning neuroimaging studies have not focussed on the motivational aspects of behaviour, such as the inherent value placed on choice itself. The experience and affective value of personal control may have particular relevance for psychiatric disorders including depression. Methods/Design In this study, we adapted an fMRI reward task that probed the value placed on exerting control over one’s decisions, termed ‘choice value’, in 122 healthy participants. We examined activation associated with choice value; personally-chosen versus passively-received rewards; and reinforcement learning metrics such as prediction error. Relationships were tested between measures of motivational orientation (categorised as Autonomy, Control and Impersonal), and subclinical depressive symptomatology. Results Anticipating personal choice activated left insula, cingulate, right inferior frontal cortex and ventral striatum (P&lt;0.05 FWE-corrected). Ventral striatal activations to choice were diminished in those with subclinical depressive symptomatology. Personally-chosen rewards were associated with greater activation of the insula/IFG, cingulate cortex, hippocampus, thalamus and substantia nigra compared to rewards that were passively received. In people who felt little control over their own behaviour (Impersonal orientation), prediction error signals in nucleus accumbens were stronger during passive trials. Discussion Previous finding regarding personal choice have been verified, and taken forward through the use of both reinforcement learning models, and correlations with psychopathology. Personal choice has an impact on the extended reward network, potentially allowing these clinically-important areas to be addressed in ways more relevant to personality styles, self-esteem and symptoms such as motivational anhedonia

Sandu, Anca-larisa

Mcneil, Christopher J.

Macfarlane, Jennifer A.

Steele, J Douglas

Mcintosh, Andrew M.

Edinburgh Research Explorer

The neurobiology of personal control during reward learning and its relation to mood

Sandu-Giuraniuc, Anca-Larisa

Delgardo, Mauricio R.

Aberdeen University Research

https://discovery.dundee.ac.uk/files/29209318/PIIS2451902218302544.pdf

The Neurobiology of Personal Control During Reward Learning and Its Relationship to Mood

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Discovery Research Portal

Edinburgh Research Explorer

Aberdeen University Research

Discovery Research Portal

Discovery Research Portal

Edinburgh Research Explorer