Introduction: CRS is a complex systemic disease affecting more than 10% of the population. There are two main types of CRS
phenotypes: CRSwNP and CRSsNP. In the Caucasian population, the prevalence of inflammation markers typical of the Th1
profile is observed in CRSsNP, whereas Th2 and Th17 in CRSwNP. Th2 inflammation is observed in the CRSwNP phenotype
with concomitant allergies, asthma or hypersensitivity to NSAIDs.
Objectives: The aim of the study was to evaluate, based on the authors’ own material, whether allergies, asthma or hypersensitivity
to NSAIDs were a risk factor for the development of a specific CRS phenotype. An attempt was also made to investigate the
influence of comorbidities on the extent of sinus endoscopic procedures, which depended on the severity of inflammation.
Methods: In the years 2006–2015, ESS was performed on 2217 patients with different CRS phenotypes. Patients with an allergy,
bronchial asthma and hypersensitivity to NSAIDs were subjected to analysis.
Results: Based on logistic regression, it was found that among the mentioned comorbidities, only asthma (P < 0.0001) and
hypersensitivity to NSAIDs (P = 0.0007) significantly affect the occurrence of the phenotype with polyps, whereas the impact
of allergies is statistically insignificant (P = 0.1909). The relationship between the type of ESS and CRS phenotypes is statistically
significant (P < 0.0001).
Conclusions: Bronchial asthma and hypersensitivity to NSAIDs have a statistically significant effect on the occurrence of the
CRSwNP phenotype. This effect was not observed in allergies. The impact of allergies, asthma and hypersensitivity on the
phenotype was observed in the group of patients subjected to the most extensive surgery (ESS 4)