Bandarra, D.

Rocha, S.

English

Hypoxia-inducible factor is a key transcriptional factor involved in the cellular response to low levels of oxygen, hypoxia. Moreover, hypoxia-inducible factor has been recently associated with a role in inflammation and immunity. Importantly, hypoxia-inducible factor is regulated by the major inflammatory responsive transcription factor, nuclear factor-?B. These two major pathways have been intimately linked. On one hand, they share a number of common target genes; on the other hand, physical interactions between hypoxia-inducible factor subunits and nuclear factor-?B have been observed. Even though the role of nuclear factor-?B over hypoxia-inducible factor is fairly well-known, the involvement of hypoxia-inducible factor over the nuclear factor-?B pathway is not. Given the overlap between these pathways, it would not be surprising to find a functional involvement of hypoxia-inducible factor in processes where nuclear factor-?B is involved. In this review, we will describe the communalities between hypoxia-inducible factor and nuclear factor-?B pathways, highlighting the crosstalk that occurs in a variety of conditions.Taken together all the communalities between hypoxia-inducible factor and nuclear factor-?B pathways, there is no doubt that a crosstalk occurs, which can potentially bring new insights for therapeutic intervention in situations of disease such as cancer, stroke or rheumatoid arthritis.<br/

University of Dundee Online Publications

Tale of two transcription factors: NF-кB and HIF crosstalk

Ac-tivity of hypoxia-inducible factor 2alpha is regulated by association with the NFkappaB essential modulator. J Biol Chem.

Alterations of CaMKII after hypoxia-ischemia during brain development. J Neurochem.

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J Biol Chem.

Crosstalk in NF-κB pathways. Nat Immunol.

EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell.

Evolutionary conserved regulation of HIF-1β by NF-κB. PLoS Genet.

Gene regulation under low oxygen: holding your breath for transcription. Trends Biochem Sci.

HIFing the brakes: therapeutic opportunities for treatment of human malignancies. Sci STKE.

Hyperglycemia regulates hypoxia-inducible factor-1al-pha protein stability and function. Diabetes.

Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification. PloS One.

Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators.

Hypoxia-responsive transcription factors. Pflugers Arch.

Kiriakidis S,Paleolog EM. Hypoxia–a key regulator of angiogenesis and inflammation in rheumatoid arthritis. Nat Rev Rheumatol.

Mechanism of hypoxia-induced NF-kappaB. Mol Cell Biol.

Mechanism of von Hippel-Lindau protein-mediated sup-pression of nuclear factor kappa B activity. Mol Cell Biol.

Negative and positive regulation of HIF-1: a complex network. Biochim Biophys Acta.

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia. J Cell Biochem.

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature.

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci USA.

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway. Nat Commun.

pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2. Mol Cell.

Regula-tion of hypoxia-inducible factor-1alpha by NF-kappaB.

Regulation of gene expression by hypoxia. Biochem J.

RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated hypoxia-inducible factor-2alpha. Nucleic Acids Res.

SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell.

The ar-chipelago ubiquitin ligase subunit acts in target tissue to restrict tracheal terminal cell branching and hypoxic-induced gene expression.

The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB- dependent transcription. Science.

The novel functions of ubiquitination in signaling. Curr Opin Cell Biol.

TRAF6 upregulates expression of HIF1α and promotes tumor angiogenesis. Cancer Res.

TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Bioessays.

Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J.

Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol.

VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2. J Cell Sci.

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Tale of two transcription factors: NF-кB and HIF crosstalk

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University of Dundee Online Publications

University of Dundee Online Publications