用共沉淀法制备Fe3O4磁性纳米粒子,并对其用油酸进行表面改性,继而采用沉淀聚合法制备壳聚糖磁性微球。考察了沉淀剂浓度、乳化剂种类、Fe3O4的改性等条件对制备微球的影响。应用扫描电镜、红外谱图、接触角仪、粒径分析仪及磁铁吸附对壳聚糖磁性微球的形态与特性进行了表征。研究结果表明,在适宜的沉淀剂浓度、复合乳化剂、Fe3O4经油酸改性等条件下,可以制得平均粒径为150 nm、单分散性好且磁性明显的壳聚糖磁性微球。The Fe3O4 nanoparticles were prepared by co-precipitation method and modified by oleic acid.Chitosan magnetic microspheres were then prepared by precipitation polymerization method.The results demonstrated that the concentration of the precipitant,the type of emulsion and the modification of the iron oxide were the most effective parameters for the preparation of the microspheres.The SEM,IR and DLS results indicated that the diameter of the microspheres was about 150nm and the microspheres were uniformly distributed.The magnetic test showed the microspheres were magnetic sensitive.国家自然科学基金(50573063);; 教育部新世纪优秀人才计划项目;; 高等学校博士点专项基金(2005038401);; 厦门大学人才基金(0000X071C1
