The authors describe here potential solutions to mitigate the risk of COVID-19 among people experiencing homelessness, emphasizing the urgent need for permanent supportive housing. They highlight the opportunities that the COVID-19 pandemic offers to heighten awareness of the harms of tobacco use and the benefits from smoking cessation. They also describe challenges to accessing telehealth primary care for people experiencing homelessness, and the roles that primary care providers and pharmacists can take to mitigate barriers to access healthcare and smoking cessation services.https://deepblue.lib.umich.edu/bitstream/2027.42/155583/1/Vijayaraghavan article.pd