【目的】 甲状腺髓样癌(medullarythyroidcarcinoma,MTC)是一种起源于能够分泌降钙素的甲状旁腺滤泡细胞的罕见的、具有侵袭性的内分泌肿瘤,该疾病以两种形式存在,即散发型甲状腺髓样癌(sporadicmedullarythyroidcarcinoma,SMTC)和遗传型甲状腺髓样癌(hereditarymedullarythyroidcarcinoma,HMTC)。HMTC又被分为多发性内分泌腺瘤2A型(MEN2A,55-60%)、多发性内分泌腺瘤2B型(MEN2B,5-10%)以及家族型甲状腺髓样癌(FMTC,35-40%)三种亚型,目前已证实RET原癌基因种系突变为...【Object】 Medullary thyroid carcinoma (MTC) is a kind of rare aggressive endocrine tumor arising from parafollicular C cells that produce calcitonin, and it exists in sporadic and hereditary forms. Hereditary medullary thyroid carcinoma (HMTC) is divided into 3 subtypes: multiple endocrine neoplasia type 2A (MEN 2A; 55–60%), multiple endocrine neoplasia type 2B (MEN 2B; 5–10%) and familial MTC...学位:医学硕士院系专业:公共卫生学院_劳动卫生与环境卫生学学号:3262014115056