Oral immunization studies relied on the live attenuated bacteria in vivo expressing antimicrobial peptides AS-prohepc2 and Scy1 in fish

Abstract

抗菌肽是鱼、虾、贝等非特异性免疫防御系统的主要成分之一,在防御外源性病原体入侵方面起着重要作用。作为一类独特的天然免疫活性物质,抗菌肽具有广谱的抗微生物活性和免疫调节活性。迄今从鱼类、甲壳动物、贝类等海洋动物中已分离获得了多种不同类型的抗菌肽,并揭示了其基因和蛋白结构以及表达特性、抗微生物活性以及某些抗菌机理;现有试验结果亦逐渐证明抗菌肽有望作为抗生素一定程度的替代品,在水产养殖业及其他行业具有应用前景,但迄今对其有效利用途径且进入机体后的免疫效应知之甚少。 天然运载载体(如细菌、病毒和哺乳动物细胞等)具有良好的体内功能和药物运载载体特性,活菌载体是其中广泛应用的载体系统之一,可将目的蛋白基...Antimicrobial peptides are considered to be one of the main components of innate immune defense system in fish, shrimp and shellfish. Antimicrobial peptides play an important role in the defense of exogenous pathogens. As a class of natural immunologically active substance, antimicrobial peptides possess broad-spectrum antimicrobial and immunomodulatory activity. So far a variety of antimicrobia...学位:理学博士院系专业:海洋与环境学院_环境科学学号:2262008015012

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