摘要 慢性肾脏病（ChronicKidneyDisease，CKD）普遍存在维生素D水平降低情况，并认为维生素D的降低与继发性甲状旁腺功能亢进（secondaryHyperparathyroidismsHPT）及降低骨密度相关。骨化三醇（Calcitriol）作为一种活性维生素D在慢性肾脏病中广泛应用，其能够有效降低iPTH水平。近年来人们发现Calcitriol在抗纤维化的过程中起重要用，本研究主要就Calcitriol能否通过上调抗衰老蛋白Klotho进而延缓肾损伤展开讨论，为证明这一假说建立了大鼠肾衰模型，全身性给予实验组大鼠Calcitriol后检测大鼠血清及组织中Klotho蛋白与...Abstract Chronic Kidney Disease (CKD) patients generally have lower vitamin D levels. It is believed that the decrease of active vitamin D is associated with the secondary hyperparathyroidism and decreased bone mineral density. As a kind of active vitamin D, calcitriol is widely used in chronic kidney disease, which can delay the process of sHPT and renal fibrosis. However, the mechanism of calci...学位：医学硕士院系专业：医学院_内科学学号：2452014115349
