Effect of Hepatitis C Virus Coinfection on the Progression of Vertically Acquired Human Immunodeficiency Virus Infection During Childhood and Adolescence

Abstract

The Pediatric National AIDS Research Network of Spain (CoRISpe) integrated in the Translational Research Network in Pediatric Infectious Diseases (RITIP).Data for a total of 57 patients vertically coinfected with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) and 365 HIV-monoinfected patients were compared until their transition to adult care. No differences regarding the dynamics of CD4 and/or CD8 T-cell counts during childhood were found. The coexistence of HCV does not increase the risk of disease progression in vertically HIV-infected patients.This study was supported by the Spanish National Pediatric Network (CoRISpe) for HIV-Infected Children and Adolescents, integrated in the Spanish AIDS Research Network (RIS), Instituto de Salud Carlos III, Spanish Health Ministry (grant RD06/0025), and a Fellowship from Gilead 2014 (GLD 14/00264). T. S. has been funded by the Spanish Society of Pediatric Infectious Diseases (ESPID Research Fellowship) and is now funded by the Spanish Ministry of Health– Instituto de Salud Carlos III (ISCIII) and cofunded by the European Union (FEDER) (Contratos Juan Rodés, grant JR16/00021)