One of the most important medical and social problems are
acute cerebrovascular disorders, among which the most part
is ischemic stroke. Known that in the development of stroke
leading role belongs to endothelial dysfunction (ED), the main
manifestation of which is the metabolic changes of the vascular
wall, the release of a significant amount endothelin-1 (EDN1)
and the development of vasoconstriction. Therefore, one of the
candidate genes, polymorphisms that can be associated with
a predisposition to the development of ED and consequently
contribute to stroke, is EDN1 gene. In order to improve the
prevention of stroke, we decided carry out a study among healthy
persons and identify possible susceptibility. The aim of our study
was to analyze the association Lys198Asn polymorphism of EDN1
gene with ischemic atherothrombotic stroke (IAS) risk factors in
the Ukrainian population
