A thyroid gland has a high ability to morphofunctional reformation under the impact of exo- and endogenous factors. Presently, the most studied are: the influence on the thyroid of ionizing radiation, temperature rate, physical activity, traumatic stress, tobacco smoke, various hormones, xenobiotics, drugs. However, in the modern scientific literature, the morphological changes in conditions of water-salt metabolism dysfunction is highlighted insufficiently

Ogbodo, Amobi

Yusupova, A.

English

SocioEconomic Challenges Journal (Sumy State University)

Міністерство освіти та науки України 
Сумський державний університет 
Медичний інституту 
 
 
 
 
 
 
 
 
 
АКТУАЛЬНІ ПИТАННЯ ТЕРЕТИЧНОЇ ТА 
ПРАКТИЧНОЇ МЕДИЦИНИ 
 
Topical Issues of Clinical and Theoretical 
Medicine 
 
 
 
 
Збірник тез доповідей  
ІV Міжнародної науково-практичної конференції 
Студентів та молодих вчених 
(Суми, 21-22 квітня 2016 року) 
 
 
 
ТОМ 1 
 
 
Суми 
Сумський державний університет 
2016 
  
 
45 СЕКЦІЯ «ЕКСПЕРИМЕНТАЛЬНА МЕДИЦИНА І» 
СОСУДИСТО-НЕРВНЫЕ СТРУКТУРЫ ОРГАНОВ ВЕРХНЕГО ЭТАЖА БРЮШНОЙ 
ПОЛОСТИ 
Щолок Т., Бурлачко Н., Скороплет А., Винниченко А. 
Научный руководитель: доцент Колесник И.Л. 
Харьковский национальный медицинский университет, кафедра анатомии человека 
Данные о нервных структурах, которые находятся в паравазальной 
соединительнотканной клетчатке в адвентициальном слое стенки кровеносных сосудов, 
весьма важны для разработки новых оперативных методик, а также в практике 
рефлексотерапии. 
Нами проведено исследование паравазальных нервов печени, желудка, 12-перстной 
кишки, селезенки на 95 трупах людей разных возрастных групп (плоды, новорожденные, 
грудной возраст, зрелый и пожилой возраст). Анализ полученных данных показал, что 
архитектура этих нервов находится в определенной зависимости от топографии и характера 
ветвления сосудов указанных органов. Нервные стволики, располагаясь вдоль артериальных 
ветвей, образуют между собой многочисленные связи. При этом зональные нервные 
сплетения чаще формируют нервные связи в виде петель. При дихотомическом делении 
артерий основные нервные стволы сплетений, подходя к воротам органов, формируют 
зональные сплетений. Проникая в орган, паравазальные нервы дают начало внутриорганным 
сплетениям, которые сопровождают одноименные артериальные ветви. Внутриорганные 
артерии сопровождают от одного до четырех нервных стволиков, которые образуют между 
собой связи в виде сплетений. 
Анализ миелоархитектоники нервов, формирующих паравазальные сплетения 
изученных органов, показал, что в них (преимущественно вблизи ворот органа) по 
количеству волокон преобладают миелиновые волокна тонкого диаметра (от 1,0 до 3,0 мкм). 
Миелиновые волокна среднего и большого диаметров встречаются в начальных отделах 
указанных нервных сплетений. Мы также установили взаимосвязь между внешним и 
внутриствольным строением нервов. Так, при рассыпной форме ветвления желудочных 
ветвей блуждающих нервов наблюдается многопучковая форма их внутриствольного 
строения. 
Указанные особенности анатомии изученных сосудисто-нервных структур следует 
учитывать при органосохраняющих операциях в практике абдоминальной хирургии. 
 
 
MORPHOLOGICAL CHANGES OF THYROID GLAND IN CONDITIONS OF 
EXTRACELLULAR DEHYDRATION OF ORGANISM 
Ogbodo Amobi, the 2th –year student, Aziza Yusupova, the 1th –year student 
Scientific supervisor – prof. Bumeister V.I. 
Sumy State University, Human Anatomy Department 
A thyroid gland has a high ability to morphofunctional reformation under the impact of exo- 
and endogenous factors. Presently, the most studied are: the influence on the thyroid of ionizing 
radiation, temperature rate, physical activity, traumatic stress, tobacco smoke, various hormones, 
xenobiotics, drugs. However, in the modern scientific literature, the morphological changes in 
conditions of water-salt metabolism dysfunction is highlighted insufficiently.  
The experiment was conducted in autumn-winter period on 12 sexually mature thoroughbred 
white male rats. The experimental animals were divided into 2 groups: control group (6 animals) 
and experimental (6 animals). The later were exposed to the artificial extracellular dehydration of a 
mild degree.   
The histological structure of the thyroid of the control-group rats is characterized by the 
prevalence of small and medium-size, oval-shaped follicles in the lobules of the gland. The follicle 
cavity is filled with a homogenous colloid pink in color. Follicular endocrine cells are mainly dark-
colored containing vacuoles in the cytoplasm; the shape is cubic. At the periphery of the lobules, 
there are based large follicles with brightly stained colloid.  
 
46 СЕКЦІЯ «ЕКСПЕРИМЕНТАЛЬНА МЕДИЦИНА І» 
During the microscopic investigation of the experimental animals’ thyroid, it was found that 
the major area of the organ in occupied by lobules of small sizes without clear division into center 
and periphery. The overall histological picture depicts tiny structure of the follicles. In the lumens 
of the majority of the follicles, there is an inconsiderable amount of desquamated epithelium. There 
are some lobules, which are separated from each other by interlayers of the hydropic stroma that has 
visually empty slots. In-between collagen interlayers of the interfollicular stroma there are found 
numerous flattened cells. In the other zones there are lobules, which are demarcated by the hydropic 
stroma to a lesser extent; the follicles vary in size: central lobules are tiny and those at the periphery 
are larger. In the tiny follicles and cellular aggregates, light-colored cells with vacuolated cytoplasm 
are prevailing. The inner contours of the tiny follicles are unclear in some areas. The lumen of the 
tiny follicles is filled with dimly eosinophilic colloid. Large follicles are generally filled with a 
colloid pink in color, some contain interfollicular epithelial outgrowths. 
Thus, on the preparations of the experimental animals, we note evidences of the 
enhancement of the thyroid functional activity, which is indicated by vacuolated cytoplasm, 
rarefaction of the colloid and the increased formation of follicles. In the peripheral areas, 
folliculogenesis is implemented by follicle fragmentation with liberation of smaller “daughter” 
follicles.  
 
 
GLOBAL METHYLATION STATUS IN MALIGNANT BRAIN TUMOR TISSUE. 
Blahovcová E.1, Richterová R.2, Kolarovszki B.2, Halašová E.1,3, Hatok J.4 
Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin (JFM CU), 
1
Biomedical Center Martin JFM CU, 
2
Clinic of Neurosurgery JFM CU and University Hospital 
Martin, 
3
Department of Medical Biology, 
4
Department of Medical Biochemistry, Martin, Slovakia 
The DNA methylation is one of the main epigenetic inheritance form, which contributes in 
the regulation of gene expression. Abnormalities in DNA methylation processes can provide 
information about many pathophysiological conditions, including tumorigenesis. DNA 
hypomethylation was the initial epigenetic abnormality recognized in human tumors. Glioblastoma 
(GB) is the most common and the most aggressive primary brain tumor in adults and therefore is 
considered one of the major issue in modern medicine. The aim of our study was to compare global 
methylation status of DNA in peripheral blood cells and in biopsy tumor tissue from patients with 
diagnosed GB using Imprint
®
 Methylated DNA Quantification Kit. Results of our study show 
global hypomethylation DNA status of GB tissues compare to global methylation DNA status of 
peripheral blood cells. Quantification of global methylation status confirm DNA hypomethylation 
in malignant brain tumor tissue, which may contribute in deregulation process of gene expression 
and subsequent tumor cell survival. Furthermore, detection of specific DNA methylation changes in 
GB tissue can subsequently help in understanding of specific genes activation and silencing through 
epigenetic events in tumor cells. 
This work was supported by the Slovak Research and Development Agency under the 
contract No. APVV-0224-12 and by the project „Biomedical Center Martin“ ITMS code: 
26220220187, the project is co-financed from EU sources. 
 
 
STRUCTURAL CHANGES OF RED BLOOD CELLS UNDER THE CONDITIONS OF 
VIOLATION OF WATER-SALT BALANCE 
Bumeister L.V., student; gr. 401 
Scientific supervisor – Prykhodko O.O. 
Sumy State University, Human Anatomy Department 
Erythrocytes are important cells in your body that travel in the blood. They are involved in a 
gas exchange that is essential to human life. Erythrocytes – unique cells in our body, which lose 
their nucleus and other cytoplasmic organelles in the period of growth.  


Morphological changes of thyroid gland in conditions of extracellular dehydration of organism

https://essuir.sumdu.edu.ua/bitstream/123456789/44928/1/Ogbodo_Amobi_morphological.pdf

Morphological changes of thyroid gland in conditions of extracellular dehydration of organism

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SocioEconomic Challenges Journal (Sumy State University)