50 % of methanolic extract Colocasia esculenta, Moringa oliefera, Luffa cylindrica, and Hibiscus esculentus were subjected to immunomodulatory activity in Swiss albino mice either sex. Mice were treated with five days of dosing of Colocasia esculenta 50 mg/kg bw, Colocasia esculenta 100 mg/kg bw, Moringa oliefera 200mg/kg bw, Moringa oleifera 400 mg/kg bw, Luffa cylindrica 100 mg/kg bw, Luffa cylindrica 200 mg/kg bw, Hibiscus esculentus 100 mg/kg bw, and Hibiscus esculentus 200 mg/kg bw. Cyclosporine (2.5 mg/kg) used as a standard reference drug for 5 days. Investigation of immunomodulator activity of these 50 % of methanolic extract of drugs to parentage of yeast digestion form 24 hours the peritoneal fluid culture and electrophoretic plasma protein band albumin, alpha 1, alpha 2, beta and gamma respectively from blood plasma were observed using parameters phagocytosis and plasma electrophoresis. Also investigated the ulcerogenic effect or any toxic effect of plant extract by histopathology study of crypt, villi and goblet cells with reference to standard drug cyclosporine. As regards these parameters, Hibiscus esculentus 100 and 200 mg/ kg bw dose, Moringa oleifera 200 and 400 mg/ kg bw dose and Luffa cylindrica 200mg/kg bw elicited a moderately significant increase in the % of yeast digestion (P < 0.001) respectively and Luffa cylindrica 100mg/kg bw significant increase in the % of yeast digestion (P < 0.01). Hibiscus esculentus showed significant dose dependent increase and Moringa oleifera decrease phagocytic activity of macrophages. Hibiscus esculentus 200 mg/ kg bw dose and Moringa oleifera 200 significantly increased (P < 0.01) the Gamma globulin.However, our present study revealed and signatured for their immunomodulator enhancing property. As in Asian subcontinent daily there vegetables are cooked and served with know and unknown of its potential function against different diseases. If there vegetables properly ruled out for their pharmacological aspect then it may add diamond in the crown of dietician which has been bother every day today life but over looked exponetentially.Keywords:- Colocasia esculenta, Moringa oliefera, Luffa cylindrica, and Hibiscus esculentu
