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小G蛋白在心肌钠通道蛋白转运中的作用
Authors
张紫冠
李卫华
+3 more
胡森
陈文博
黄峥嵘
Publication date
15 December 2018
Publisher
Abstract
目的研究小G蛋白Sar1和Arf1对钠通道蛋白(Nav1.5)转运的调控作用。方法以HEK293细胞作为宿主细胞,将人SCN5A基因转染到HEK293细胞中,通过G418筛选稳定表达SCN5A基因的细胞系;为了检测小G蛋白对Nav1.5的调节效应,野生型或突变型的小G蛋白Sar1和ARF1分别瞬转到HEK293-Nav1.5细胞。利用免疫印迹对目标蛋白进行定量,应用免疫荧光对细胞内的目标蛋白进行定位。结果过表达突变的Sar1减少了细胞膜上Nav1.5的表达和抑制了Nav1.5转运到细胞膜上。另外,过表达ARF1对于Nav1.5在细胞的表达及定位无明显影响。结论小G蛋白Sar1可能参与调节Nav1.5在细胞内的运输。福建省自然科学基金资助项目(2015J01563
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Last time updated on 10/06/2020