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IDH1突变体通过抑制JNK的激活减少生长因子缺失诱导的细胞凋亡
Authors
Ai Chen
Bin Jiang
+19 more
Furong Lin
Huamin Zhou
Huanhuan Ma
Jia Zhang
Jinmei Xia
Jinyang Wang
Li-Man Hung
Lianzhong Luo
Lin Zhou
Minggang Shi
Muhammad Suleman
Qingwen Zhao
Tak Wah Mak
Wentao Zhao
Xiaotong Li
Yan Zhang
Yanan Wu
Ying He
李勤喜
Publication date
25 April 2018
Publisher
Abstract
文章简介抵抗凋亡和能在血清营养因子缺乏的情况下生长是肿瘤细胞的两个主要特征。JNK的激活是血清饥饿诱导的细胞凋亡所必须的因素。目前研究表明IDH1突变体产生的致癌代谢物2-羟基戊二酸(2-HG)是突变的导致肿瘤形成的主要原因。然而目前尚不清楚2-HG是否能抑制JNK的激活,进而使细胞抵抗血清饥饿诱导的凋亡。课题组以IDH1 R132Q的基因敲入MEF为研究对象
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Last time updated on 10/06/2020