The Inhibitory Effect of GSNO to Endometrial Cancer and Preliminary Study of the Mechanisms

Abstract

目的:近年来子宫内膜癌发病率不断上升,严重影响女性健康,目前子宫内膜癌治疗手段仍以传统的手术治疗为主,辅以放疗、化疗、内分泌治疗等,毒副作用大,对患者的生活质量及恢复造成不良影响。分子靶向治疗药物具有特异性强,毒副作用小等优势,成为目前肿瘤治疗界的研究热点。S-亚硝基谷胱甘肽(GSNO)已被证实对多种恶性肿瘤有治疗作用。本课题拟通过体内外实验,探究GSNO对子宫内膜癌细胞生长的抑制作用,并对其可能的作用机制进行初步探讨,为子宫内膜癌的分子靶向治疗提供新的思路。 方法:采用CCK8法检测GSNO对子宫内膜癌细胞HEC-1-A以及ishikawa的生长抑制作用,通过HE染色法观察GSNO对细胞形...OBJECTIVE: The incidence of endometrial cancer is continually rising in recent years, seriously impact women’s health. The treatment of endometrial cancer remains given to surgery, supplemented with radiotherapy, chemotherapy, endocrinotherapy and so on. All of these make serious toxic and side dffects, badly impact on the patient’s quality of life and recovery. Molecular targeted therapy is one k...学位:医学硕士院系专业:医学院_妇产科学学号:2452014115356

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