目的：临床研究发现大多数心肌炎患者都伴随着延长的QRS波群（≥120ms），而延长的QRS波群增加了心脏疾病患者的死亡风险。本文通过心肌炎大鼠模型探究心电图QRS波群的延长与心室肌中主要的缝隙连接通道蛋白Cx43368位磷酸化的相关性。 方法：通过给予大鼠皮下注射猪的心室肌肌球蛋白建立EAM（experimentalautoimmunemyocarditis）实验动物模型，观察心肌炎病程中大鼠心电图的变化。采用Westernblot和免疫组化方法检测心肌组织中Cx43的磷酸化水平和分布情况。在细胞水平探究EAM大鼠血清和IL-1β引起Cx43368位磷酸化相关信号通路的激活；采用离体心脏灌流...Objective: Clinical studies have found that most patients with myocarditis are accompanied by prolonged QRS complex (≥ 120ms), and prolonged QRS complex is an independent risk factor for mortality in heart diseases. In the present study, utilizing experimental autoimmune myocarditis (EAM) as a disease model, we explored the correlation of abnormal QRS complex and pS368Cx43 in the ventricular myoca...学位：理学博士院系专业：医学院_生理学学号：2452013015433
