背景:随着全球经济发展和社会竞争力的逐渐激烈,抑郁症的发病率不断增高,给社会和家庭带来了巨大的负担,已经成为世界性公共卫生问题。胃肠功能紊乱作为抑郁症的躯体症之一,是抑郁症的一种共病表现,对患者的生活质量造成了很大的影响。开心散(Kai-Xin-San,KXS)是一种治疗情志疾病的古方,对抑郁症疗效确切,但对抑郁症胃肠共病的疗效和机制却少有报道。根据抑郁症以及抑郁症胃肠共病的发病机制,我们选择川芎、缬草两味中药对开心散原方进行加味组成开心散加味方(thenovelModifiedKai-Xin-San,KXS-(+)),以提高其抗抑郁效果以及改善胃肠功能。 方法:本实验采用清洁级2月龄雄性S...Objective: As the global economic development and gradually fierce social competitiveness, the incidence of depression is increasing. Depression brought a huge burden to the society and family, and it has become a worldwide public health problem. Gastrointestinal dysfunction as one of the body disease of depression, is a kind of comorbidities with depression, and depression brings significant imp...学位:医学硕士院系专业:医学院_内科学学号:2452014115349