摘要 研究背景 类固醇激素受体的辅激活因子（steroidreceptorcoactivatorSRC）作为一类转录的协同因子，能够和多种转录因子进行相互作用并且增强其转录活性。SRC-1隶属于SRC家族，现在已经有的研究结果显示SRC-1在体内可以具有多种生物学功能。SRC-1可以参与乳腺癌、前列腺癌和肝细胞癌等多种肿瘤的增殖和入侵。SRC-1在脑内突触的可塑性、神经干细胞的分化等过程中具有重要的调控作用。此外，SRC-1基因敲除可以削弱雌激素对血管损伤后的保护作用，从而加重血管损伤后的新生内膜的形成。尽管已有的研究结果表明SRC-1在心血管系统中内皮细胞、血管平滑肌细胞以及心肌细胞都有...ABSTRACT Research Background Steroid receptor coactivator-1 (SRC-1) is a member of the SRC family which functions as a transcriptional coactivator for nuclear receptors and other transcription factors,and enhance its transcriptional activity. Multiple physiological roles of SRC-1 have been revealed, SRC-1 may be involved in the proliferation and invasion of breast cancer, prostate cancer, ...学位：医学硕士院系专业：医学院_内科学学号：2452014115350
