Effect of oleoylethanolamide on the recovery of motor function during the chronic phase after cerebral ischemia in mice and its mechanism

Abstract

研究背景:缺血性脑卒中是致残率最高的疾病,患者长期伴有躯体感觉运动功能障碍等脑缺血慢性损伤,给患者及家庭带来极大的痛苦和沉重的负担。目前临床上,对于脑缺血慢性损伤尚无有效的治疗药物,因此,研究和寻找改善脑缺血慢性损伤的药物具有十分重要的意义。研究发现脑缺血损伤慢性期,脑损伤周边区过度激活的星形胶质细胞合成和释放细胞外基质如Neurocan等,可抑制轴突再生,阻碍神经功能恢复。过氧化物酶体增殖物激活受体α(peroxisomeproliferator-activatedreceptor,PPARα)属于核受体超家族,是一类配体激活的核转录因子。我们前期研究发现PPARα激动剂油酰乙醇胺(oleo...Background: Cerebral ischemic stroke is a disease of the highest morbidity in the world. Patients are always accompanied with chronic cerebral ischemia injury such as long-term motor dysfunction. And it brings huge pain and heavy burden to patients and their families. Currently, there are still no effective drugs for the treatment of chronic cerebral ischemia injury. Therefore, it is of great sign...学位:医学硕士院系专业:医学院_药理学学号:2452014115359

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