核受体Nur77是核受体（NuclearReceptors，NRs）超家族中非常重要的一个孤儿核受体。作为细胞内立早基因的产物，Nur77能够在细胞微环境变化的刺激下被迅速上调或修饰，发挥其生物学功能。同时，Nur77能够广泛的参与到生物机体的生理与病理活动中，如：生物代谢、自噬、线粒体自噬、炎症发生发展以及肿瘤组织的生长凋亡等过程。转化生长因子（TransformingGrowthFactorβ，TGF-β）信号通路几乎作用于所有的细胞组织，能广泛调控包括生物代谢、细胞外基质更替、细胞的增殖与分化、组织的纤维化以及肿瘤发生凋亡等多种生理病理进程。对TGF-β信号通路的调控研究一直是TGF-β...Nur77 is one of the most unique member of nuclear receptor superfamily. As an immediate early responsive gene product, Nur77 responds to a variety of microenvironment stimuli, including various growth factors and inflammatory factors. Nur77 participates widely in physiological and pathological processes, such as cell metabolism, autophagy, mitophagy, inflammation, and tumor growth and apoptosis. T...学位：医学硕士院系专业：药学院_药理学学号：3232014115342
