艾滋病是因感染HIV病毒而引起的一种死亡率高,传播范围广的免疫缺陷综合征。高效抗逆转录病毒疗法一度被认为是治疗HIV的良方,尽管高效抗逆转录病毒疗法可以将病毒载量降低至检测限以下,但却不能从根本上根除病毒,因为病毒颗粒会潜伏在“病毒库”中,一经停药,病毒又会“卷土重来”。因此,科学家们提出了一种新的疗法——shock&kill,就是先用激活剂将包藏在CD4+T细胞中的病毒激发出来,再联用HAART以及自身免疫系统将其一举消灭。 RNAPolⅡ是真核生物转录过程最重要的聚合酶,在转录延伸阶段,P-TEFb作为一个转录延伸因子,可以磷酸化RNAPolⅡ的CTD区域,以及负性转录因子DSIF和NE...AIDs is a kind of Immune deficiency syndrome that can cause a high rate of fatality and widely spreading, Which is caused by HIV infection. Highly active antiretroviral therapy was considered a good treatment for HIV, However, although the viral load can be reduced to lower than detection limit by HAART, It cannot fundamentally eradicate the virus. Because virus particles can hide themselves into ...学位:医学硕士院系专业:药学院_药理学学号:3232014115343