非酒精性脂肪肝是一直困扰我国和全世界人口的慢性疾病，发病率在20%左右，也就是说每5个中国人，就有一个是非酒精性脂肪肝的携带者。而FDA推荐的《非酒精性脂肪肝病诊疗指南》中，并没有明确有效的预防和治疗非酒精性脂肪肝的药物。所以，明确肝脏细胞脂质代谢的调控机制，筛选出可以改善脂质堆积的药物是迫在眉睫的。本课题通过80份病例的分析，试图寻找到能够调控脂质代谢中关键的转录因子SREBP-1c的蛋白。我们使用组织免疫的方法来检测患者肝脏穿刺样品中的Nur77表达量。结果发现，随着病情的加重Nur77表达量逐步降低，而SREBP-1c的含量则有显著地上调。随后，我们又建立了非酒精性脂肪肝的细胞体外和小鼠...Nonalcoholic fatty liver is a chronic disease that has plagued our country and the world's population. The incidence rate is about 20%, which means there is one non-alcoholic fatty liver carrier every five Chinese people. Even though in FDA recommended "non-alcoholic fatty liver disease diagnosis and treatment guidelines", there is no clear and effective prevention and treatment of non-alcoholic f...学位：理学硕士院系专业：药学院_化学生物学学号：3232014115339
