海洋微生物是结构新颖、活性显著化合物的重要来源。海洋微生物天然产物具有抗肿瘤、抗菌、抗病毒、抗氧化等广谱的生物活性,在药物研发过程中占据举足轻重的地位。 本论文以两株红树林根际土壤真菌(Eutypellasp.1-13、Chaetomiumsp.0227-13-3)和一株海藻共附生曲霉(Aspergillussp.ZL01b-14)为研究对象,对这三株海洋真菌的次级代谢产物进行了分离纯化以及结构鉴定,共从中分离到43个单体化合物,包括14个新化合物。 红树林真菌弯孢聚壳属Eutypellasp.1-13采用了含10%NaCl的大米培养基,从中共分离到化合物10个,其中新化合物7个。包括7个...Marine microorganism has been to become a significant source of novel and bioactive secondary metabolites in recent years. Marine microorganism natural products with broad spectra of bioactivities such as anti-tumor, antibiotic, antivirus, anti-oxidation, have a high status in the pharmaceutical industry. In this thesis, we choose two mangrove soil fungi (Eutypella sp. 1-13、Chaetomium sp. 0227-13...学位:理学硕士院系专业:生命科学学院_微生物学学号:2162014115244