MicroRNA（miRNA）是真核生物中一类小的内源性非编码单链RNA，通过靶向作用于信使RNA（mRNA），其在基因的转录和翻译过程中起到至关重要的作用。MiR-411-5p（之前又被称为miR-411）与人类许多疾病的发生发展相关。然而，miR-411-5p与乳腺癌的关系至今未被研究透彻。本研究中，我们发现，相对于正常乳腺组织，miR-411-5p在乳腺癌中是低表达的；同时，与正常乳腺细胞MCF-10A相比，miR-411-5p在乳腺癌细胞系中也是低表达的。本研究发现，在乳腺癌细胞中过表达miR-411-5p后，不论是在体外还是体内，miR-411-5p都可以抑制乳腺癌细胞的增殖与转移。...MicroRNAs (miRNAs) are small noncoding RNAs that have a pivotal role in the post-transcriptional regulation of gene expression by sequence-specifically targeting multiple mRNAs. MiR-411-5p (previously called miR-411) is severely involved in human diseases, however, the relationship between miR-411-5p and breast cancer has not been investigated thoroughly. Here, we found that the expression levels ...学位：医学硕士院系专业：医学院_外科学学号：2452014115355
