The construction and evaluation of allogeneic common carotid artery transplantation model in rats and explore the effects of atorvastatin on this model

Abstract

研究目的 近年来各外科器官移植手术、心血管内科介入手术、心脏外科血管搭桥手术广泛开展,这些手术有一些共同的特点,无论是外来的移植器官、金属支架,或是自体的静脉移植,都会在术后引起强烈的炎症反应。器官移植是治疗终末期器官衰竭的有效办法,然而,外来移植物可引起强烈的炎症反应和排斥反应,并且移植物也会反过来影响宿主的生活状态;心内科介入手术植入的金属支架尽管不会引发强烈排斥反应,但也会导致无菌性炎症反应;而心脏搭桥血管虽然常取自自体静脉,但是术后也会发生静脉血管动脉化的转变,这一过程中同样涉及复杂的炎症反应。因此,上述几类术后宿主针对移植物的各种排斥反应和炎症反应以及移植物对宿主的各种不良影响逐步...Research Objective In recent years, solid organ transplantation, cardiovascular interventional surgery and coronary artery bypass surgery have been widely carried out, these procedures have some common characteristics, whether it is the transplant organs, metal stents, or autologous vein graft, they are all cause a strong inflammatory response after surgery. Organ transplantation is an effective ...学位:医学硕士院系专业:医学院_内科学学号:2452014115349

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